Aging and Degenerative Disc Changes of the IVD’s Impact on Spinal Flexibility A publication reviewed several studies involving the biomechanics of the intervertebral discs (IVD) with macroscopic changes associated with degenerative disc disease with the aim of finding out how spinal flexibility was affected by dehydration, tears, fissures, osteophytes, and the inevitable collapse of the […]
A research study of GABAergic communication within rodent peripheral sensory ganglia demonstrated that somatosensory pain signals can be transmitted from the peripheral sensory nerves to the central nervous system (CNS). The study further found that necessary proteins required in GABA synthesis were released by sensory neurons and triggered by depolarization. By infusing the sensory ganglia […]
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Numerous studies have examined disc volume, height, and fluid flow to more clearly understand the effects and rate of cellular diffusion and nutrient and waste transfer on IVD. However, to date, there have been no significant measurements of the rate at which discs lose fluids during normal activity throughout the day. We know that IVD […]
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A review 1 of how biochemical and micromechanical events affect the cellular biology and morphology of intravertebral discs (IVD) during physical motion, loading, and compression determined that important interactions between the nucleus pulposus and annular fibrosis altered cells, micromechanical, mechanobiological, and mechanical features. Because previous studies have indicated a strong genetic link in the propensity […]
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Study Finds Prolapse Injury Influenced by Flexion Degree and Level of Hydration, not Rate of Loading
A study 1 of isolated and adapted bovine spinal segments examined the extent to which flexion, hydration, and loading rates were responsible for the breakdown of the nucleus pulpous structure and found that the rate of loading had little effect on disc damage with full annular division. Instead, the degree of flexion and the hydration […]
A 2015 study of 36 chronic pain patients sought to explore the causes of pain-related fear in the hopes of contributing to research that might help practitioners develop avoidance models in the future. The study found that the most common cause of pain-related fear is its inexplicability and unpredictability—because patients could not make any reasonable […]
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